HLAB*15:02 Genotyping
iPROMISE has developed a genotyping test kit for the detection of HLAB*15:02 variant, which has a high association with Steven-Johnson Syndrome (SJS) / toxic epidermal necrolysis (TEN). The Food and Drug Administration (FDA, USA) recommends that individuals of Asian ancestry be genotyped for the presence of the HLA-B*1502 variant prior to receiving carbamazepine or phenytoin to avoid adverse drug reactions
*we are currently in the process of applying for ISO 15189
iPROMISE has developed a genotyping test kit for the detection of HLAB*15:02 variant, which has a high association with Steven-Johnson Syndrome (SJS) / toxic epidermal necrolysis (TEN). The Food and Drug Administration (FDA, USA) recommends that individuals of Asian ancestry be genotyped for the presence of the HLA-B*1502 variant prior to receiving carbamazepine or phenytoin to avoid adverse drug reactions
*we are currently in the process of applying for ISO 15189
Other Genotyping Services
| VKORC1 | : Warfarin resistance and sensitive |
| CYP2D6 | : Ultra-rapid and poor metaboliser of antipsychotic drugs |
| CYP2C19 | : Clopidogrel resistance |
| CYP3A5 | : Tacrolimus toxicity |
| CYP2C9 | : Warfarin and NSAIDs toxicity |
