Research Direction
The centre mainly focuses on:
- Training young researchers in the field of bioinformatics such as; human and bacterial genomics, in-depth metabolomics analysis, and protein modeling.
- Engaging in collaborative research with national and international institutes in the genomics field.
- Design and development of genotyping kits in collaboration with the ISBC.
- Providing bioinformatics services.
Research Scope:
1. Human genomics
Quality control, processing and analysis of raw human genome data to extrapolate information relevant to health, population, migration studies.
2. Bacterial genomics
Quality control, processing and analysis of raw bacterial genome data to extrapolate information relevant to pathogenicity, virulence, phylogenetic and phylogenomic patterns, and resistance evolution.
3. Bacterial metagenomics
Analysis of multispecies bacterial samples derived from multiple sources (e.g. stool), for the relevant studies (e.g. health and cognition).
Selected Publications:
1. Systematic characterization and comparison of the CYP2C9 variability of the Orang Asli in Malaysia with 12 populations
Impact Factor: 1.764
DOI: http://dx.doi.org/10.1016/j.dmpk.2016.04.004
2. Detection of CYP2C19 Genetic Variants in Malaysian Orang Asli from Massively Parallel Sequencing Data
Impact Factor: 3.54
DOI: http://dx.doi.org/10.1371/journal.pone.0164169
3. Increased risks of cardiovascular diseases and insulin resistance among the Orang Asli in Peninsular Malaysia
Impact Factor: 3.00
DOI: 10.1186/s12889-016-2848-9
