iPROMISE has developed a genotyping test kit for the detection of HLAB*15:02 variant, which has a high association with Steven-Johnson Syndrome (SJS) / toxic epidermal necrolysis (TEN). The Food and Drug Administration (FDA, USA) recommends that individuals of Asian ancestry be genotyped for the presence of the HLA-B*1502 variant prior to receiving carbamazepine or phenytoin to avoid adverse drug reactions.
*we are currently in the process of applying for ISO 15189
Other Genotyping Services
|VKORC1||: Warfarin resistance and sensitive|
|CYP2D6||: Ultra-rapid and poor metaboliser of antipsychotic drugs|
|CYP2C19||: Clopidogrel resistance|
|CYP3A5||: Tacrolimus toxicity|
|CYP2C9||: Warfarin and NSAIDs toxicity|